For the most part, playing on a phone isn't much different than a PC. However, there are a few areas that are more difficult to manipulate without a mouse such as sliding players up and down a draft board or depth chart. It's still doable though.
By no means am I complaining about the mobile friendliness of this site. I'm only stating that this game would reach a much wider audience and bring in a lot more cash if it were available in app stores. Mobile interface tweaks aside.