Week 2 |
|
| Washington @ Carolina (-3) | |
| New Orleans (-11) @ Denver | |
| Buffalo @ Kansas City (-4) | |
| Dallas @ Arizona (-16) | |
| San Francisco @ Atlanta (-3) | |
| Tampa Bay @ Oakland (-9) | |
| Houston (-7) @ Miami | |
| Green Bay @ Minnesota (-1) | |
| Detroit @ Chicago (-1) | |
| New York (N) (-9) @ New England | |
| New York (A) @ Los Angeles (A) (-2) | |
| Jacksonville @ Baltimore (even) | |
| Indianapolis @ Pittsburgh (-1) | |
| Cleveland (-6) @ Tennessee | |
| Cincinnati @ Los Angeles (N) (even) | |
| Philadelphia @ Seattle (even) | Game of the week |
Week 4 |
|
| Atlanta (-1) @ Minnesota | |
| Tennessee @ Indianapolis (-5) | |
| Miami @ Cleveland (-7) | |
| New England (-1) @ Denver | |
| New York (A) @ Oakland (-9) | |
| Washington @ Dallas (-6) | |
| Seattle @ San Francisco (-10) | |
| Cincinnati @ Buffalo (-4) | |
| Jacksonville @ Chicago (even) | Game of the week |
| Philadelphia @ Green Bay (-5) | |
| New York (N) (-12) @ Los Angeles (N) | |
| Pittsburgh @ Houston (-18) | |
| Baltimore @ Los Angeles (A) (even) | |
| New Orleans (-5) @ Kansas City | |
| Tampa Bay @ Carolina (even) | |
| Arizona (-6) @ Detroit | |
Week 9 |
|
| Los Angeles (N) @ Philadelphia (-4) | |
| Miami (-8) @ Washington | |
| New York (A) @ New York (N) (-18) | |
| Minnesota @ New Orleans (-15) | |
| New England @ Dallas (even) | |
| Los Angeles (A) @ Buffalo (-8) | |
| Seattle @ Arizona (-18) | |
| Cincinnati @ Houston (-18) | |
| Indianapolis @ Jacksonville (-3) | |
| Detroit @ Tennessee (-2) | |
| Chicago @ Atlanta (-6) | |
| Green Bay (-3) @ Carolina | |
| Denver @ Tampa Bay (-4) | |
| Kansas City @ Oakland (-4) | |
| Cleveland (-6) @ Pittsburgh | |
| San Francisco @ Baltimore (even) | Game of the week |
Week 10 |
|
| Seattle @ Cincinnati (-8) | |
| Indianapolis @ Tennessee (-1) | |
| Green Bay @ Jacksonville (-5) | |
| Cleveland (-3) @ Oakland | |
| Miami (-2) @ New England | |
| Los Angeles (A) @ Kansas City (-9) | |
| New Orleans (-10) @ Tampa Bay | |
| Denver @ Atlanta (-9) | |
| Buffalo (-1) @ New York (A) | |
| Philadelphia @ New York (N) (-17) | |
| Dallas @ Washington (even) | |
| San Francisco @ Arizona (-11) | |
| Pittsburgh @ Los Angeles (N) (even) | Game of the week |
| Houston (-13) @ Baltimore | |
| Minnesota @ Chicago (-4) | |
| Carolina @ Detroit (-10) | |
Week 11 |
|
| Jacksonville @ Cleveland (-10) | |
| Los Angeles (N) @ Baltimore (-5) | |
| Minnesota @ Detroit (-6) | |
| Cincinnati @ San Francisco (-5) | |
| Seattle @ Washington (-2) | |
| New Orleans (-13) @ Carolina | |
| Atlanta @ Oakland (-4) | |
| New England @ New York (A) (even) | Game of the week |
| Denver @ Los Angeles (A) (-3) | |
| Buffalo @ Miami (-7) | |
| Dallas @ Philadelphia (-4) | |
| Arizona @ New York (N) (-5) | |
| Kansas City @ Pittsburgh (-1) | |
| Tampa Bay @ Green Bay (-6) | |
| Chicago @ Tennessee (-4) | |
| Indianapolis @ Houston (-16) | |
Week 14 |
|
| Minnesota @ Los Angeles (N) (-2) | |
| Jacksonville @ Detroit (-2) | |
| Cleveland (-7) @ Baltimore | |
| Washington @ San Francisco (-11) | |
| Carolina @ Seattle (-4) | |
| Atlanta @ New Orleans (-11) | |
| Oakland @ New England (even) | Game of the week |
| Denver @ New York (A) (-4) | |
| Miami (-6) @ Los Angeles (A) | |
| Buffalo @ Philadelphia (even) | |
| New York (N) (-12) @ Dallas | |
| Arizona (-7) @ Pittsburgh | |
| Kansas City (-2) @ Tampa Bay | |
| Tennessee @ Green Bay (-3) | |
| Houston (-13) @ Chicago | |
| Indianapolis @ Cincinnati (-1) | |
Week 16 |
|
| Houston (-10) @ Indianapolis | |
| Pittsburgh @ New England (-3) | |
| Baltimore @ Cincinnati (-4) | |
| Cleveland @ Arizona (-4) | |
| Atlanta (-1) @ Philadelphia | |
| Green Bay @ New Orleans (-13) | |
| Chicago @ Detroit (-5) | |
| Minnesota (-1) @ Carolina | |
| Los Angeles (N) @ Tampa Bay (-3) | |
| San Francisco (-4) @ Seattle | |
| Dallas @ New York (N) (-18) | |
| New York (A) @ Washington (even) | Game of the week |
| Tennessee @ Jacksonville (-5) | |
| Miami (-1) @ Buffalo | |
| Denver @ Kansas City (-9) | |
| Oakland (-4) @ Los Angeles (A) | |